Joaquin Phoenix and Lady Gaga are causing chaos as Joker and Harley Quinn in the latest trailer for Warner Bros. and DC‘s “Joker: Folie à Deux,” the sequel to 2019’s “Joker.” The film is set to release in theaters on Oct. 4, 2024 after world premiering in competition at the Venice Film Festival, where the first movie won the Golden Lion in 2019.

Both a critical and commercial success, the first “Joker” was nominated for 11 Oscars, with star Joaquin Phoenix winning best actor and Hildur Guðnadóttir for original score. It became the highest-grossing R-rated movie in history. The sequel will have Phoenix reprise his role, accompanied by Gaga’s Harley Quinn, as the two embark on sinister adventures. The film will reportedly take place mostly in Arkham Asylum.

Brendan Gleeson, Catherine Keener, Jacob Lofland and Harry Lawtey comprise the supporting cast of “Joker: Folie à Deux,” with Zazie Beetz returning as Sophie from the original. The sequel is said to be a musical, expanding on Phoenix’s manic dancing from the first movie.

Addressing the movie’s musical components, Beetz told Variety: “I think people will be surprised. I don’t think it’s going to be what they expect, around it being musical. We all sort of express musically and dancing in our lives day-to-day. I think it’s going to work really well.”

“Joker: Folie à Deux” will be separate from the other upcoming films from DC Studios co-CEOs James Gunn and Peter Safran’s slate, like “Superman,” and exist in its own separate world. The same goes for Matt Reeves’ “The Batman: Part II,” which tells its own standalone story. Gaga’s Harley Quinn will exist separately from Margot Robbie’s character, seen in “Birds of Prey” and “The Suicide Squad,” and Kaley Cuoco’s animated character from the Max series.

Todd Phillips returns as director of “Joker: Folie à Deux.” He co-wrote the script with Scott Silver and produced the film with Bradley Cooper.